Testosterone stimulation

A 31-year-old man presenting with an 18-month history of sexual dysfunction resulting from severe adult-onset IHH (LH U/L, FSH U/L, T nmol/L). Initial therapy with 50 mg of clomiphene citrate (CC) three times a day for 7 days, with overnight LH pulse profiling and 9 am T levels evaluated at baseline and on completion. A 2-month washout period, followed by low-dose maintenance therapy (25-50 mg/d) for 4 months.
MAIN OUTCOME MEASURE(S):Baseline and stimulated T levels and LH pulsatility; effect on sexual function.
RESULT(S):Clomiphene therapy resulted in complete normalization of pulsatile gonadotropin secretion, serum T level, and sexual function. CONCLUSION(S):Isolated hypogonadotropic hypogonadism may result from an acquired defect of enhanced hypothalamic sensitivity to E-mediated negative feedback. Whereas direct T replacement therapy can further suppress endogenous gonadotropin secretion, treating IHH men with gonadotropins can stimulate endogenous T secretion and enhance fertility potential. On theoretical grounds, reversal of gonadotropin deficiency with CC might be expected to have a similar biological effect.

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The increase when sexually aroused is minor and transient, with +/-/l in the sexually aroused group and +/- nmol/l in control. The arousal does not need to be great, as testosterone increases are seen even after social interaction with attractive females. [10] [11] After a 5 minute conversation with an attractive woman, male testosterone levels can increase up to 30% from baseline (relative to an increase of 13% for conversing with males). [11] This degree of testosterone increase is unlikely to exert any anabolic effect on muscle tissue, but can contribute to neurology.

Testosterone stimulation

testosterone stimulation

The increase when sexually aroused is minor and transient, with +/-/l in the sexually aroused group and +/- nmol/l in control. The arousal does not need to be great, as testosterone increases are seen even after social interaction with attractive females. [10] [11] After a 5 minute conversation with an attractive woman, male testosterone levels can increase up to 30% from baseline (relative to an increase of 13% for conversing with males). [11] This degree of testosterone increase is unlikely to exert any anabolic effect on muscle tissue, but can contribute to neurology.

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