1540s, earlier sinthoma (late 14c.), from Medieval Latin sinthoma "symptom of a disease," from Late Latin symptoma , from Greek symptoma (genitive symptomatos ) "a happening, accident, disease," from stem of sympiptein "to befall," from syn- "together" (see syn- ) + piptein "to fall," from PIE *pi-pt- , reduplicated form of root *pet- "to rush; to fly" (see petition (n.)). Spelling altered in English by influence of Middle French and Late Latin forms. Symptomatic in general sense of "indicative (of)" is from 1751.
Resistance to ketoconazole has been observed in a number of clinical fungal isolates, including Candida albicans . Experimentally, resistance usually arises as a result of mutations in the sterol biosynthesis pathway. Defects in the sterol 5-6 desaturase enzyme reduce the toxic effects of azole inhibition of the 14-alpha demethylation step. Multidrug-resistance (MDR) genes can also play a role in reducing cellular levels of the drug. As azole antifungals all act at the same point in the sterol pathway, resistant isolates are normally cross-resistant to all members of the azole family.  
Testosterone is significantly correlated with aggression and competitive behaviour and is directly facilitated by the latter. There are two theories on the role of testosterone in aggression and competition.  The first one is the challenge hypothesis which states that testosterone would increase during puberty thus facilitating reproductive and competitive behaviour which would include aggression.  Thus it is the challenge of competition among males of the species that facilitates aggression and violence.  Studies conducted have found direct correlation between testosterone and dominance especially among the most violent criminals in prison who had the highest testosterone levels.  The same research also found fathers (those outside competitive environments) had the lowest testosterone levels compared to other males.