What amazed me about the relationship between Hypothyroidism and testosterone: For decades I had trouble with muscle development. I have been using synthroid for my Hashimotos Hypothyroidism. I recently switch to Naturethroid (a natural bio-identical hormone replacement,) and within 8 weeks, my muscles began to grow! I don’t think that changing from synthetic to natural analog was as much to blame for the growth as was the serendipitous increase in Free T3. I have a conversion problem that kept me from converting the T4 into T3. The Free T3 levels had always been within a “normal” range but at the bottom third of that range. Titrating The Naturethroid, which contains T3 as well as T4, to achieve Free T3 levels in the upper third of the range changed everything. I’ve not checked Free testosterone, but anecdotally — dramatic muscle increases globally, and oddly enough my voice decreased into a deeper tone. Overall more cheerful and clear headed.
A team led by Dr. Joel Finkelstein at Massachusetts General Hospital investigated testosterone and estradiol levels in 400 healthy men, 20 to 50 years of age. To control hormone levels, the researchers first gave the participants injections of a drug that suppressed their normal testosterone and estradiol production. The men were randomly assigned to 5 groups that received different amounts (from 0 to 10 grams) of a topical 1% testosterone gel daily for 16 weeks. Half of the participants were also given a drug to block testosterone from being converted to estradiol.
“The trials’ results indicate that, for older men with low sexual function, testosterone treatment can contribute to improved function,” said Evan Hadley, ., director of NIA’s Division of Geriatrics and Clinical Gerontology. “In contrast, though, the results don’t indicate that testosterone treatment for older men with low walking ability or vitality will improve these conditions to a great extent. Additional trial arms tested effects on other aging-related outcomes, and we are looking forward to their results to help provide further insights into testosterone use in older men.” Older men should consult their physicians if considering a testosterone treatment, Hadley emphasized.