Simvastatin occasionally causes myopathy manifested as muscle pain, tenderness or weakness with creatine kinase (CK) above ten times the upper limit of normal (ULN). Myopathy sometimes takes the form of rhabdomyolysis with or without acute renal failure secondary to myoglobinuria, and rare fatalities have occurred. The risk of myopathy is increased by elevated plasma levels of simvastatin and simvastatin acid. Predisposing factors for myopathy include advanced age (≥65 years), female gender, uncontrolled hypothyroidism , and renal impairment.
Regardless of the phase of use or Equipoise doses in question, most men will need an anti- estrogen to combat this steroids aromatase activity. EQ does not aromatize heavily, but it does present enough estrogenic activity to promote related effects. Human Growth Hormone ( HGH ) is also a fantastic addition to any plan during any phase of use, and it is one of the most well-tolerated hormones you’ll ever come across. However, it is extremely expensive, requires long-term use (extremely long-term ) and we cannot call it essential.