Additional analyses showed that testosterone reduces levels of certain transcription factors (regulatory proteins) that ordinarily prevent Module 52 genes from “turning on.” In other words, higher testosterone levels result in more Module 52 expression. Several Module 52 genes have known immune-system connections; activation of one of these genes, for example, results in the accelerated differentiation of cells whose job it is to suppress, rather than foster, immune response. These connections make the interactions of the genes with testosterone an intriguing target of further exploration by immunologists, physiologists and drug researchers, Davis said.
This is a common problem with pellets. If you go looking for forums on the matter, you will see that it is rather typical for patients to have a similar response somewhere around the 4th and 5th implantation. This stems from poor oversight/management, and design flaws in the pellets themselves. Keep in mind that all pellets are made the same way. This may seem beneficial at first glance, however, what this really means is that “6 months” worth of medication dissolves in a way that sends your levels far too high in the first month, and then plummeting far too fast and low in the next 2-3.