Haloperidol decanoate injection site

The dose of Haldol Decanoate 50 or Haldol Decanoate 100 should be expressed in terms of its haloperidol content. The starting dose of haloperidol decanoate should be based on the patient's age, clinical history, physical condition, and response to previous antipsychotic therapy. The preferred approach to determining the minimum effective dose is to begin with lower initial doses and to adjust the dose upward as needed. For patients previously maintained on low doses of antipsychotics (. up to the equivalent of 10 mg/day oral haloperidol), it is recommended that the initial dose of haloperidol decanoate be 10–15 times the previous daily dose in oral haloperidol equivalents; limited clinical experience suggests that lower initial doses may be adequate.

The influence of renal impairment on the pharmacokinetics of haloperidol has not been evaluated. About one-third of a haloperidol dose is excreted in urine, mostly as metabolites. Less than 3% of administered haloperidol is eliminated unchanged in the urine. Haloperidol metabolites are not considered to make a significant contribution to its activity, although for the reduced metabolite of haloperidol, back-conversion to haloperidol cannot be fully ruled out. Even though impairment of renal function is not expected to affect haloperidol elimination to a clinically relevant extent, caution is advised in patients with renal impairment, and especially those with severe impairment, due to the long half-life of haloperidol and its reduced metabolite, and the possibility of accumulation (see section ).

Fluphenazine came into use in 1959. [6] The injectable form is on the World Health Organization's List of Essential Medicines , the most effective and safe medicines needed in a health system . [7] It is available as a generic medication . [1] In the United States the tablets costs between and USD per day for a typical dose. [1] The wholesale cost in the developing world of the long acting form is between and USD per injection as of 2014. [8] It was discontinued in Australia around mid 2017. [9]

2 to 5 mg IM single dose initially; use if oral therapy is not appropriate; may administer as frequently as 1 hour intervals, though dosing every 4 to 8 hours is satisfactory for most patients. Max: 20 mg/day IM. Repeat doses based on clinical response and safety considerations. Geriatric patients may require a lower dose; use lower starting dose and titrate gradually. Use the lowest effective dose in all patients. Convert to oral therapy as soon as clinically indicated. Second generation antipsychotics with efficacy for this indication (oral or parenteral, ., risperidone, olanzapine, or ziprasidone), may be preferred due to cardiac and extrapyramidal risks of parenteral haloperidol. In some patients, the addition of a benzodiazepine may be needed. SWITCHING TO ORAL THERAPY: In general, the parenteral dose administered in the preceding 24 hours may be used as the total initial daily PO dosage. Thereafter, closely monitor and adjust oral dosage to efficacy and tolerance. Usually, the first oral dose should be given within 12 to 24 hours following the last IM dose.

Haloperidol decanoate injection site

haloperidol decanoate injection site

2 to 5 mg IM single dose initially; use if oral therapy is not appropriate; may administer as frequently as 1 hour intervals, though dosing every 4 to 8 hours is satisfactory for most patients. Max: 20 mg/day IM. Repeat doses based on clinical response and safety considerations. Geriatric patients may require a lower dose; use lower starting dose and titrate gradually. Use the lowest effective dose in all patients. Convert to oral therapy as soon as clinically indicated. Second generation antipsychotics with efficacy for this indication (oral or parenteral, ., risperidone, olanzapine, or ziprasidone), may be preferred due to cardiac and extrapyramidal risks of parenteral haloperidol. In some patients, the addition of a benzodiazepine may be needed. SWITCHING TO ORAL THERAPY: In general, the parenteral dose administered in the preceding 24 hours may be used as the total initial daily PO dosage. Thereafter, closely monitor and adjust oral dosage to efficacy and tolerance. Usually, the first oral dose should be given within 12 to 24 hours following the last IM dose.

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