Haldol decanoate antidote

Haloperidol is a typical butyrophenone type antipsychotic that exhibits high affinity dopamine D 2 receptor antagonism and slow receptor dissociation kinetics. [41] It has effects similar to the phenothiazines . [17] The drug binds preferentially to D 2 and α 1 receptors at low dose (ED 50 = and  mg/kg, respectively), and 5-HT 2 receptors at a higher dose (ED 50 =  mg/kg). Given that antagonism of D 2 receptors is more beneficial on the positive symptoms of schizophrenia and antagonism of 5-HT 2 receptors on the negative symptoms, this characteristic underlies haloperidol's greater effect on delusions, hallucinations and other manifestations of psychosis. [42] Haloperidol's negligible affinity for histamine H 1 receptors and muscarinic M 1 acetylcholine receptors yields an antipsychotic with a lower incidence of sedation, weight gain, and orthostatic hypotension though having higher rates of treatment emergent extrapyramidal symptoms .

EPS during the administration of HALDOL (haloperidol) have been reported frequently, often during the first few days of treatment. EPS can be categorized generally as Parkinson-like symptoms, akathisia, or dystonia (including opisthotonos and oculogyric crisis). While all can occur at relatively low doses, they occur more frequently and with greater severity at higher doses. The symptoms may be controlled with dose reductions or administration of antiparkinson drugs such as benztropine mesylate USP or trihexyphenidyl hydrochloride USP. It should be noted that persistent EPS have been reported; the drug may have to be discontinued in such cases.

There are no well controlled studies with Haldol (haloperidol) in pregnant women. There are reports, however, of cases of limb malformations observed following maternal use of Haldol along with other drugs which have suspected teratogenic potential during the first trimester of pregnancy. Causal relationships were not established in these cases. Since such experience does not exclude the possibility of fetal damage due to Haldol, this drug should be used during pregnancy or in women likely to become pregnant only if the benefit clearly justifies a potential risk to the fetus.

processing.... Drugs & Diseases haloperidol (Rx) Brand and Other Names: Haldol, Haldol Decanoate, more... Haloperidol LA, Peridol

  • Classes: Antipsychotics, 1st Generation
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Sections haloperidol (Rx)
  • Sections haloperidol
  • Dosing & Uses
  • Interactions
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  • Pregnancy
  • Pharmacology
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Dosing & Uses Adult Pediatric Geriatric Dosage Forms & Strengths tablet

Haldol decanoate antidote

haldol decanoate antidote

processing.... Drugs & Diseases haloperidol (Rx) Brand and Other Names: Haldol, Haldol Decanoate, more... Haloperidol LA, Peridol

  • Classes: Antipsychotics, 1st Generation
  • Share
  • Email
  • Print
  • Feedback
Close
  • Facebook
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  • Google+
Sections haloperidol (Rx)
  • Sections haloperidol
  • Dosing & Uses
  • Interactions
  • Adverse Effects
  • Warnings
  • Pregnancy
  • Pharmacology
  • Administration
  • Images
  • Patient Handout
  • Formulary
Dosing & Uses Adult Pediatric Geriatric Dosage Forms & Strengths tablet

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