If playing together with other instruments, it is helpful to understand that every instrument in a mix takes up space in the sonic spectrum. Think of the available sonic space as a box, where only so much bass is available, only so many mid-range frequencies are available, and only so much treble’s available before you run into the top of the box. If too many instruments compete for a certain frequency range, things just won’t sound as good and tight as they need to be. An EQ pedal can help sculpt your sound to sit better in the mix. Is your guitar too bassy and competing with the actual bass guitar? Use your EQ pedal to roll off the bass. Can the piano not be heard as clearly because of your chunky rhythm playing? Use your EQ pedal to roll off those mid and high frequencies. Is your Fender Strat sounding too harsh? Mellow out those mid-range frequencies.
¶ Dose reduction and/or serum Theophylline concentration measurement is indicated whenever adverse effects are present, physiologic abnormalities that can reduce Theophylline clearance occur (., sustained fever), or a drug that interacts with Theophylline is added or discontinued (see WARNINGS ).
Once-Daily Dosing: The slow absorption rate of this preparation may allow once-daily administration in adult non-smokers with appropriate total body clearance and other patients with low dosage requirements. Once-daily dosing should be considered only after the patient has been gradually and satisfactorily titrated to therapeutic levels with q12h dosing. Once-daily dosing should be based on twice the q12h dose and should be initiated at the end of the last q12h dosing interval. The trough concentration (C min ) obtained following conversion to once-daily dosing may be lower (especially in high clearance patients) and the peak concentration (C max ) may be higher (especially in low clearance patients) than that obtained with q12h dosing. If symptoms recur, or signs of toxicity appear during the once-daily dosing interval, dosing on the q12h basis should be reinstituted.
It is essential that serum Theophylline concentrations be monitored before and after transfer to once-daily dosing.
Food and posture, along with changes associated with circardien rhythm, may influence the rate of absorption and / or clearance rates of Theophylline from extended-release dosage forms administered at night. The exact relationship of these and other factors to nighttime serum concentrations and the clinical significance of such findings require additional study. Therefore, it is not recommended that Theophylline extended-release once-daily dosing be administered at night.
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