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Concern pertains to the potential for cross-resistance or co-resistance to other antimicrobials. Numerous studies have been performed and there have been results indicating that the use of biocidal agents, such as triclosan, can cause cross-resistance. Results from a study published in The American Journal of Infection Control showed that exposure to triclosan was associated with a high risk of developing resistance and cross-resistance in Staphylococcus aureus and Escherichia coli . This was not observed with exposure to chlorhexidine or a hydrogen peroxide -based agent (during the conditions in said study). [71]

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